Another Alternative
Vitiligo Treatment SCAM?
>>> from the perspective of an accountant, a professional auditor
most importantly, An EX-Vitiligo Patient ...
WARNING!
Don't buy ANY anti-vitiligo product
before you read this article
It may *NOT* be what you think!
Don't buy ANY anti-vitiligo product
before you read this article
It may *NOT* be what you think!
Dear frustrated vitiligo patient,
I'm sick and tired of reading all these stuff, probably you are too.
"... anti-vitiligo this ... anti-vitiligo that ... coupled with mind-boggling bodacious claims ... 85% success rate, permanent cure, clinically proven, tested and approved by medical professionals ... etc."If you have been googling a fair bit for vitiligo related information, you are bound to come across them.
The question is ...
Are all these anti-vitiligo products
for real ... really work ... or scams?
for real ... really work ... or scams?
Few readers had written to me and asked these million-dollar questions ...
1. Have you tried anti-vitiligo?Here's one of the many emails received ...
2. Does anti-vitiligo really work?
3. Is anti-vitiligo supported by any solid scientific studies?
4. If your vitiligo has not been cured yet, would you give anti-vitiligo a try? If yes, why? If no, why?
QUOTE
"Message: Does anti-vitiligo really works? i got vitiligo patches on my arm, and i nearly never take off my sweater becouse i want to hide my arm, so no can see my vitiligo patches, ive had vitiligo for 5 years or so now, and its getting on my nerves more and more, so plz, i want to know if antivitiligo works."
UNQUOTE
1. No, I've not tried anti-vitiligo.Why?
2. I'm as curious as you are to find out whether anti-vitiligo really work.
3. I did some in-depth research on the active ingredients used in anti-vitiligo at the medical library. Findings will be presented below, read them.
With this knowledge, I believe you'll be able to draw your own conclusion ... whether anti-vitiligo really work and should you give it a try.
4. I don't mind giving it a try, *IF* and only if the active ingredients are supported by authoritative evidence-based scientific researches that proven to support vitiligo treatment without adverse side-effects.
What do I have to lose?
EXCEPT vitiligo!
EXCEPT vitiligo!
However, if the active ingredients are not supported by solid scientific research or it does has adverse side-effects, such as skin cancer, etc, I will certainly drop it ... throw it ... chuck it ... and never look at it again.
The right attitude
is the KEY to freedom ...
is the KEY to freedom ...
One of the distinct attitude and behaviour of vitiligo patients who manage to say "good-bye" to their vitiligo is that they never give-up in seeking out possible treatments that may work, when current treatments show little or no results.
They are ever prepared to try something new, provided the proposed possible treatment has reasonable scientific basis and without adverse side-effects.
Now, I'm not suggesting that you try anything ... everything ... blindly. That's very dangerous.
Why?
I'll explain later.
My suggestion is, try it ... IF and only if the proposed vitiligo treatment has reasonable scientific basis and without adverse side-effects.
I've to admit that this cautiously optimistic "adventurous attitude" of mine is the KEY that enabled me to finally say "good-bye" to my vitiligo too, just like many others who had repigmentation.
How I did it is another story ... nothing to do with anti-vitiligo that we are discussing today.
The deciding factor
to try OR not to try
to try OR not to try
In my opinion, the DECIDING FACTOR whether or not you should give anti-vitiligo a try or a miss, much depend on the answer to this million-dollar question ...
Are the active ingredients
supported by solid scientific studies
that proven to work ... to support
vitiligo treatment, without side-effects?
supported by solid scientific studies
that proven to work ... to support
vitiligo treatment, without side-effects?
As far as I know, there are few different anti-vitiligo products in the market.
One is cream based, another is in tablet form while the remaining are in oil-based form. ALL calling themselves - anti-vitiligo. Incidentally, all are from Pakistan.
All made very impressive product claims, with equally impressive testimonials and money-back guarantee policy.
Listen-up: don't get sucked-in by those impressive claims easily. Adopt a neutral position. Don't write-off those impressive claims, neither should you accept them as the gospel truth.
Instead, let's examine whether can the product support itself, first and foremost. If the product can't even support itself, then throw all those bodacious claims out of the window ... of course the products too.
What are the anti-vitiligo products
in the market?
in the market?
There's no need to list down ALL anti-vitiligo products in the market here.
Why?
Because the deciding factor as to which anti-vitiligo product you should consider trying lies in the answer to this question ...
Are the active ingredients supported by reasonable scientific studies that's proven to work ... to support vitiligo treatment, without adverse side-effects?So, let's ask ourselves ...
Which anti-vitiligo product in the market
meet this deciding factor?
I was utterly shocked ... surprised and amazed to find out ... only one, yes only ONE anti-vitiligo product revealed the active ingredients used.
CLICK HERE to find out, which anti-vitiligo product I'm referring to. Is this the anti-vitiligo product that you are evaluating too? Do that before you read further, because it will enables you to understand the following arguments and findings better.
The other anti-vitiligo products merely states that their anti-vitiligo products are "pure herbal oil" or "herbal remedy for re-pigmentation in vitiligo".
Fine, the anti-vitiligo products are made of herbs, but what are the herbs used to produce the said pure herbal oil or herbal remedy remain a mystery.
I really wonder ...
Why the other anti-vitiligo product owners
are so reluctant to reveal the active ingredients
used in their products?
are so reluctant to reveal the active ingredients
used in their products?
Need to protect their trade secret? That's NOT an acceptable reason. Why? Because the trade secret is NOT in what the active ingredients are.
The trade secrets should be ...
... how to extract the active ingredients from the raw materials, to maintain its beneficial properties
... the proportion of each of the active ingredients used in the anti-vitiligo product
... the preparation of the anti-vitiligo product itself, eg, to cook, boil, soak, hard-press, cold-press, for how long, etc
... how they maintain consistency of the product quality, to ensure each bottle or tablet has the same potency and efficacy
... etc.
I'm NOT interested in those technical details
Are you?
Are you?
SIDE-NOTE:
If any of the anti-vitiligo product owners do read this review, may I challenge them to reveal the active ingredients used, so that we vitiligo pateints/consumers could have more choices.
So, toss them ...
Why?
Because without knowing what are the herbs used, there's no way to find out whether the active ingredients used in those anti-vitiligo products are ...
1) ... scientifically proven to support your vitiligo treatment,Personally, I will never use any vitiligo treatment product on my vitiligo lesions, whether oral or topical, without first knowing what are the active ingredients in the product.or could be ...
2) ... detrimental to your vitiligo conditions.
Why?
Because from my extensive research, I know for a fact that some of the herbs used in certain alternative vitiligo treatment products are actually harmful to vitiligo conditions. Yes, scientifically proven to be detrimental.
Why?
Because skin depigmentation occurs due to either the immune cells in the body are killing the melanocyte (the cells that produce pigment molecules and give the skin its color) or the melanocyte are attacking and killing themselves. In short, vitiligo is caused by an over-active immune system.
As the melanocytes die, the skin turns white.
This is the most widely accepted pathogenesis of vitiligo and thus far, no medical authority has ever disputed that.
Many traditional medicine herbs are known to boost the immune system. On the premise that vitiligo is caused by an over-active immune system, any active ingredients that boost the immune system could be detrimental.
You need something that could modulate your immune system, not one that boost (over-active) or weaken ( under-active) the immune system.
Hence, one wrong active ingredient could cause undesirable reactions, and set your immune cells or melanocytes on over-drive mode, causing your vitiligo lesions to spread like wild fire ... fast and uncontrollably.
I won't take the risk of using any vitiligo treatment product, be it oral or topical, without first knowing what are the active ingredients in the product.
Would you?
Ignore this advice at your own rsk!
Ignore this advice at your own rsk!
Hence, the choice is automatically narrowed down to only ONE anti-vitiligo product that you should consider using.
Yes, the anti-vitiligo product that we know what the active ingredients are.
Next, come another million-dollar question ...
Are these active ingredients
supported by scientific studies
in relation to vitiligo treatment?
supported by scientific studies
in relation to vitiligo treatment?
I've been to the medical library and did some in-depth research on the active ingredients used in this particular anti-vitiligo.
1. Coconut Oil
What? Applying coconut oil on my vitiligo lesions?! No way, dude ...
Honestly, that was my initial reaction. However, as I dig deeper and know more of the wonders of coconut oil, I had a paradigm shift.
We all know that oil become rancid pretty fast. This is why leftover foods become stale very fast too.
Do you know that coconut oil is slow to oxidize and thus resistant to rancidity, lasting up to two years due to its high saturated fat content?
According to a researcher, coconut oil is the only type of oil you should use on your skin because coconut oil will be absorbed easily, keep the skin soft and yet without the greasy feel.
Every 100g of coconut oil contains 0.1mg of Vitamin E Alpha Tocopherol, a well-known potent antioxidant that we all know is beneficial to the skin.
According to an authoritative evidence-based scientific study, coconut oil is proven to be a ...
Here's the said scientific study ...
Coconut oil will make your skin softer, smoother and moist.
Hence, I've no problem with coconut oil as an active ingredient in this anti-vitiligo product.
Do you?
2. Psoralea Corylifolia (also known as Babachi)
Psoralen occurs naturally in the seeds of Psoralea corylifolia.
Psoralens are photo-sensitizing agents, meaning they react with ultraviolet (UV) light to cause darkening of the skin.
Proof?
PUVA (Psolaren + UVA), both topical and oral, is the oldest method of vitiligo treatment.
The name PUVA itself suggests that Psolaren is a key element in this treatment.
In topical PUVA, a thin coat of psoralen is applied to the patient's depigmented patches about 30 minutes before UVA light exposure.
This treatment is often used for people with a small number of depigmented patches (affecting less than 20 percent of the body). It is also used for children 2 years old and older who have localized patches of vitiligo.
In oral PUVA therapy, the patient takes a prescribed dose of psoralen by mouth about 2 hours before exposure to artificial UVA light. The doctor adjusts the dose of light until the skin areas being treated become pink.
Oral PUVA therapy is used for people with more extensive vitiligo (affecting greater than 20 percent of the body) or for people who do not respond to topical PUVA therapy.
For both topical and oral PUVA, UVA imust be administered and monitored by a dermatologist.
For patients who cannot go to a PUVA facility, the doctor may prescribe psoralen to be used with natural sunlight exposure. This is known as PUVA-SOL.
In addition, phenolic compounds in Psoralea corylifolia were shown to be effective in protecting biological membranes against various oxidative stresses.
Here's a scientific study to support this claim.
In another scientific study, Psoralea corylifolia seed extract has been found to stimulate the immune system in mice.
Here's a scientific study to support this claim ...
From all the above positive findings about Psoralea corylifolia on vitiligo, I've no problem with this active ingredient in this antivitiligo product.
I believe you too.
After all, Psoralen is a time tested treatment for vitiligo, and no one can dispute that simple fact.
3. Black Cumin
Black cumin refers to seeds derived from a plant with the botanical name Nigella sativa.
Below is a very important and interesting finding about Nigella sativa.
Read this ...
Immunomodulatory properties simply means ... having the ability to alter or regulate one or more immune functions.
In other words, it enables immune system modification during treatment: the modification of some aspect of the immune system as part of a treatment, especially the suppression of the immune system in order to encourage the body to accept another part of the same body.
To put it in another way, Black Cumin is an immunosuppressant or an immunostimulator based on its effect on the immune system.
It has the abilities to modulate the immune system, preventing it from being over or under active.
In simple layman's terms, it modulates the immune system accordingly ... not too hot, not too cold ... just right.
On the premise that vitiligo is an auto-immune disease, meaning skin depigmentation occurs because of an over-active immune system [the immune cells of the body are killing the melanocyte (the cells that produce pigment molecules and give the skin its color) or the melanocyte are attacking and killing themselves], the immunomodulatory properties of Black cumin in modulating the immune system, preventing the immune system from being over or under active, is indeed a very powerful property.
This immunomodulatory properties is powerful because it does not merely treat the symptoms of vitiligo (depigmented skin) but rather arrest the root cause of vitiligo, which is a far better and more effective way of treatment.
I'm really excited about this interesting and important finding about Black Cumin, and I think you should too.
But ...
Cytotoxic: used to describe a drug that prevents cell division, often used in cancer treatment. Also used to describe a type of cell in the immune system that destroys other cells.
Immunosuppressive cytotoxic agent simply means a substance that can suppress the immune system thus preventing a type of cell in the immune system that destroys other cells.
On the premise that vitiligo is an auto-immune disease, isn't such properties are what we wanted in vitiligo treatment?
I've no problem at all with Black Cumin as an active ingredient in this antivitiligo product.
Do you?
4. Barberry Root
The botanical name of Barberry Root is Berberis vulgaris.
The primary chemical constituents of Barberry include alkaloids (berberine, berbamine, oxyacanthine), chelidonic acid, resin and tannins.
This herb also contains the B-vitamin thiamine, vitamin C, the carotenoids beta-carotene, lutein, and zeaxanthin, chromium, cobalt, and zinc.
Here's an interesting and important finding on the antioxidant and cytoprotective properties of this herb, in relation to another pathogenesis of vitiligo - oxidative stress.
In order to appreciate the antioxidant and cytoprotective activity in Barberry Root, one has to understand another pathogenesis of vitiligo ... oxidative stress.
Oxidative stress is an over-accumulation of hydrogen peroxide in the skin. Every person develops hydrogen peroxide in the skin, as a result of natural biological processes. An enzyme called "catalase" normally breaks down the hydrogen peroxide in the skin into water and oxygen.
However, some people with vitiligo may have a problem manufacturing, using or delivering catalase to the skin.
Again, I've no problem with Barberry Root as an active ingredient in this antivitiligo product.
Why?
Let's recap ...
... Because it has photo-sensitizing agent, to cause darkening of your skin especially with the help of natural sunlight, liken to PUVA-SOL.
... Because it has anti-oxidative properties, to guard against oxidative stress, the undesirable accumulation of hydrogen peroxide in your skin.
... Because it has immunomodulatory properties, to modulate your immune system, preventing it from being over-active or under-active.
Conclusion: this anti-vitiligo product may work for you, and it does NOT seems to be a scam.
I seriously don't think you should take the risk to try any other anti-vitiligo product, simply because the active ingredients used in those anti-vitiligo products are NOT make known to you.
It's just not wise ... for reasons already explained earlier.
Ignore this sincere advice at your own risk.
From the above findings, it appears this anti-vitiligo product ... works.
The truth is, if you don't try, you won't know.
The fact that this anti-vitiligo product do have reasonable scientific basis to its claims, is a good and comforting point to start with ... to give it a try.
I've done reviews on many alternative vitiligo treatment products. It's a fact that many alternative treatment products DON'T have any scientific basis to their bodacious claims.
This anti-vitiligo product is one of the rare exceptions.
In addition, this anti-vitiligo product comes with an ...
Here are money-back guarantee for two other anti-vitiligo product, of which the active ingredients are not revealed.
Heck, with such a generous 60 day free trial, go ahead and try this anti-vitiligo product for at least 60 days. If you are not happy with the results you get, simply ask for a refund.
CLICK HERE to find out which anti-vitiligo product I'm talking about, if you have NOT done so.
Sorry, I'll NOT reveal here all the other anti-vitiligo products that I strongly suggest that you drop, dump, toss ... and never look at.
Why?
Because that will be seen as bad-mouthing others and it's distasteful. It's my policy to do NO harm to others.
Till next time ...
Here's wishing you speedy repigmentation of your vitiligo lesions with this anti-vitiligo product.
Peace!
Michael DeAngelo
EX-Vitiligo Patient
who is blessed with 100% repigmentation
P.S.: If you have vitiligo at sensitive areas, eg. around the eyes, lips, arm pit, nipple and genital, certain treatments such as steroid and PUVA may not be suitable treatment due to undesirable side-effects - thinning of skin and burns. This anti-vitiligo oil may be a good alternative treatment.
P.P.S.: If you are one of those who refuses to give Elidel pimecrolimus or Protopic tacrolimus a try, due to fear of developing skin cancer from using these drugs, you may want to give this natural product a try then. It's safe.
SIDE-NOTESHere are my findings ...
Before the publication of this article, even the producer of this anti-vitiligo product has NO idea of the scientific basis of the active ingredients used in their product, because it was NEVER mentioned in their website earlier. After the publication of this article, they have since taken the main points from my research findings in this article and posted them in their website.
1. Coconut Oil
What? Applying coconut oil on my vitiligo lesions?! No way, dude ...
Honestly, that was my initial reaction. However, as I dig deeper and know more of the wonders of coconut oil, I had a paradigm shift.
We all know that oil become rancid pretty fast. This is why leftover foods become stale very fast too.
Do you know that coconut oil is slow to oxidize and thus resistant to rancidity, lasting up to two years due to its high saturated fat content?
This is largely due to
the anti-oxidative effect of coconut oil.
the anti-oxidative effect of coconut oil.
According to a researcher, coconut oil is the only type of oil you should use on your skin because coconut oil will be absorbed easily, keep the skin soft and yet without the greasy feel.
Every 100g of coconut oil contains 0.1mg of Vitamin E Alpha Tocopherol, a well-known potent antioxidant that we all know is beneficial to the skin.
According to an authoritative evidence-based scientific study, coconut oil is proven to be a ...
Safe and effective
moisturizer for your skin
moisturizer for your skin
Here's the said scientific study ...
DermatitisOK, it's proven that coconut oil has anti-oxidative effect and is a safe and effective moisturizer that's good for the skin.
2004 Sep;15(3):109-16
A randomized double-blind controlled trial comparing extra virgin coconut oil with mineral oil as a moisturizer for mild to moderate xerosis.
Department of Dermatology, Makati Medical Center, Makati City, Philippines.
Here's the abstract ...
BACKGROUND: Xerosis is a common skin condition (1) characterized by dry, rough, scaly, and itchy skin, (2) associated with a defect in skin barrier function, and (3) treated with moisturizers. People in the tropics have effectively used coconut oil as a traditional moisturizer for centuries. Recently, the oil also has been shown to have skin antiseptic effects. A moisturizer with antiseptic effects has value, but there are no clinical studies to document the efficacy and safety of coconut oil as a skin moisturizer.
OBJECTIVE: This study aimed to determine the effectivity and safety of virgin coconut oil compared with mineral oil as a therapeutic moisturizer for mild to moderate xerosis.
METHODS: A randomized double-blind controlled clinical trial was conducted on mild to moderate xerosis in 34 patients with negative patch-test reactions to the test products. These patients were randomized to apply either coconut oil or mineral oil on the legs twice a day for 2 weeks. Quantitative outcome parameters for effectivity were measured at baseline and on each visit with a Corneometer CM825 to measure skin hydration and a Sebumeter SM 810 to measure skin lipids. For safety, transepidermal water loss (TEWL) was measured with a Tewameter TM210, and skin surface hydrogen ion concentration (pH) was measured with a Skin pH Meter PH900. Patients and the investigator separately evaluated, at baseline and at each weekly visit, skin symptoms of dryness, scaling, roughness, and pruritus by using a visual analogue scale and grading of xerosis.
RESULTS: Coconut oil and mineral oil have comparable effects. Both oils showed effectivity through significant improvement in skin hydration and increase in skin surface lipid levels. Safety was demonstrated through no significant difference in TEWL and skin pH. Subjective grading of xerosis by the investigators and visual analogue scales used by the patients showed a general trend toward better (though not statistically evident) improvement with coconut oil than with mineral oil. Safety for both was further demonstrated by negative patch-test results prior to the study and by the absence of adverse reactions during the study.
CONCLUSION: Coconut oil is as effective and safe as mineral oil when used as a moisturizer.
Coconut oil will make your skin softer, smoother and moist.
Hence, I've no problem with coconut oil as an active ingredient in this anti-vitiligo product.
Do you?
2. Psoralea Corylifolia (also known as Babachi)
Psoralen occurs naturally in the seeds of Psoralea corylifolia.
Psoralens are photo-sensitizing agents, meaning they react with ultraviolet (UV) light to cause darkening of the skin.
Psoralen ...
is a time tested treatment for vitiligo
is a time tested treatment for vitiligo
Proof?
PUVA (Psolaren + UVA), both topical and oral, is the oldest method of vitiligo treatment.
The name PUVA itself suggests that Psolaren is a key element in this treatment.
Topica PUVA
In topical PUVA, a thin coat of psoralen is applied to the patient's depigmented patches about 30 minutes before UVA light exposure.
This treatment is often used for people with a small number of depigmented patches (affecting less than 20 percent of the body). It is also used for children 2 years old and older who have localized patches of vitiligo.
Oral PUVA
In oral PUVA therapy, the patient takes a prescribed dose of psoralen by mouth about 2 hours before exposure to artificial UVA light. The doctor adjusts the dose of light until the skin areas being treated become pink.
Oral PUVA therapy is used for people with more extensive vitiligo (affecting greater than 20 percent of the body) or for people who do not respond to topical PUVA therapy.
PUVA-SOL
For both topical and oral PUVA, UVA imust be administered and monitored by a dermatologist.
For patients who cannot go to a PUVA facility, the doctor may prescribe psoralen to be used with natural sunlight exposure. This is known as PUVA-SOL.
Effectiveness of PUVA
International Journal of DermatologyFrom the above findings, the active ingredient Psoralea corylifolia in antivitiligo is expected to have some positive effect on vitiligo treatment, especially when vitiligo lesions are exposed to natural sunlights, after application of antivitiligo, just like PUVA-SOL treatment explained above.
1999 Jul;38(7):542-5
PUVA treatment of vitiligo: a retrospective study of Turkish patients.
Department of Dermatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Here's the abstract ...
BACKGROUND:
Psoralen plus ultraviolet A (PUVA) is considered to be the treatment of choice for subtotal vitiligo; however, it is time consuming and carries certain health risks for both patients and physicians. This study attempts to evaluate the efficacy of the treatment in Turkish vitiligo patients.
METHODS:
We have performed a retrospective study of 33 patients with vitiligo who received systemic PUVA therapy during the period 1985 to 1997, and have evaluated their response to treatment.RESULTS:
Overall, 28 patients (84%) showed some improvement; 12 patients experienced a repigmentation of 51-75% and six patients achieved greater than 75% repigmentation.
The age of the patient, age at onset of the disease, sex, disease duration, and degree of depigmentation prior to initiation of therapy had NO influence on PUVA-induced repigmentation.
Psoralea corylifolia
has oxidative stress properties?
has oxidative stress properties?
In addition, phenolic compounds in Psoralea corylifolia were shown to be effective in protecting biological membranes against various oxidative stresses.
Here's a scientific study to support this claim.
Phytotherapy ResearchOxidative stress is widely accepted as one of the probable cause of vitiligo. Hence, the protective oxidative stress properties in Psoralea corylifolia suggest that it's beneficial for vitiltgo treatment.
2002 Sep;16(6):539-44
Antioxidative components of Psoralea corylifolia (Leguminosae).
Faculty of Engineering, Fukuyama University, Gakuen-cho, Japan.
Here's the abstract ...
A meroterpene and four flavonoids were isolated from the seeds of Psoralea corylifolia as antioxidative components.
Their structures were elucidated by spectral data and identified as bakuchiol (1), bavachinin (2), bavachin (3), isobavachin (4) and isobavachalcone (5).
In particular, meroterpene 1 and flavonoids 4 and 5 showed broad antioxidative activities in rat liver microsomes and mitochondria.
They inhibited NADPH-, ascorbate-, t-BuOOH- and CCl(4)-induced lipid peroxidation in microsomes. They also prevented NADH-dependent and ascorbate-induced mitochondrial lipid peroxidation.
Bakuchiol (1) was the most potent antioxidant in microsomes and the inhibition of oxygen consumption induced by lipid peroxidation was time-dependent.
Furthermore, bakuchiol (1) protected human red blood cells against oxidative haemolysis.
These phenolic compounds in P. corylifolia were shown to be effective in protecting biological membranes against various oxidative stresses.
Psoralea corylifolia
stimulate the immune system
stimulate the immune system
In another scientific study, Psoralea corylifolia seed extract has been found to stimulate the immune system in mice.
Here's a scientific study to support this claim ...
FitoterapiaAuto-immunity is another widely accepted probable cause of vitiligo. Hence, the protective oxidative stress properties in Psoralea corylifolia suggest that it's beneficial for vitiltgo treatment.
2000 Jun;71(3):223-31
Immunomodulatory and antitumour properties of Psoralea corylifolia seeds.
Ethnomedicine and Ethnopharmacology Division, Tropical Botanic Garden and Research Institute (TBGRI), Palode, Trivandrum, India.
Here's the abstract ...
Psoralea corylifolia seed extract has been found to stimulate the immune system in mice.
Administration of the extract was found to inhibit EAC ascitic tumour growth and stimulate natural killer cell activity, antibody-dependent cellular cytotoxicity, antibody-forming cells and the antibody complement-mediated cytotoxicity during tumour development.
From all the above positive findings about Psoralea corylifolia on vitiligo, I've no problem with this active ingredient in this antivitiligo product.
I believe you too.
After all, Psoralen is a time tested treatment for vitiligo, and no one can dispute that simple fact.
3. Black Cumin
Black cumin refers to seeds derived from a plant with the botanical name Nigella sativa.
Below is a very important and interesting finding about Nigella sativa.
Read this ...
International Immunopharmacology
2005 Dec;5(13-14):1749-70. Epub 2005 Jul 1
Immunomodulatory and therapeutic properties of the Nigella sativa L. seed
Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, USA.
Here's the abstract ...
A larger number of medicinal plants and their purified constituents have been shown beneficial therapeutic potentials.
Seeds of Nigella sativa, a dicotyledon of the Ranunculaceae family, have been employed for thousands of years as a spice and food preservative.
The oil and seed constituents, in particular thymoquinine (TQ), have shown potential medicinal properties in traditional medicine.
In view of the recent literature, this article lists and discusses different immunomodulatory and immunotherapeutic potentials for the crude oil of N. sativa seeds and its active ingredients.
The published findings provide clear evidence that both the oil and its active ingredients, in particular TQ, possess reproducible anti-oxidant effects through enhancing the oxidant scavenger system, which as a consequence lead to antitoxic effects induced by several insults.
The oil and TQ have shown also potent anti-inflammatory effects on several inflammation-based models including experimental encephalomyelitis, colitis, peritonitis, oedama, and arthritis through suppression of the inflammatory mediators prostaglandins and leukotriens.
The oil and certain active ingredients showed beneficial immunomodulatory properties, augmenting the T cell- and natural killer cell-mediated immune responses.
Most importantly, both the oil and its active ingredients expressed anti-microbial and anti-tumor properties toward different microbes and cancers.
Coupling these beneficial effects with its use in folk medicine, N. sativa seed is a promising source for active ingredients that would be with potential therapeutic modalities in different clinical settings.
The efficacy of the active ingredients, however, should be measured by the nature of the disease.
Given their potent immunomodulatory effects, further studies are urgently required to explore bystander effects of TQ on the professional antigen presenting cells, including macrophages and dendritic cells, as well as its modulatory effects upon Th1- and Th2-mediated inflammatory immune diseases.
Ultimately, results emerging from such studies will substantially improve the immunotherapeutic application of TQ in clinical settings.
Immunomodulatory properties ...
What does that really mean?
What does that really mean?
Immunomodulatory properties simply means ... having the ability to alter or regulate one or more immune functions.
In other words, it enables immune system modification during treatment: the modification of some aspect of the immune system as part of a treatment, especially the suppression of the immune system in order to encourage the body to accept another part of the same body.
To put it in another way, Black Cumin is an immunosuppressant or an immunostimulator based on its effect on the immune system.
It has the abilities to modulate the immune system, preventing it from being over or under active.
In simple layman's terms, it modulates the immune system accordingly ... not too hot, not too cold ... just right.
On the premise that vitiligo is an auto-immune disease, meaning skin depigmentation occurs because of an over-active immune system [the immune cells of the body are killing the melanocyte (the cells that produce pigment molecules and give the skin its color) or the melanocyte are attacking and killing themselves], the immunomodulatory properties of Black cumin in modulating the immune system, preventing the immune system from being over or under active, is indeed a very powerful property.
This immunomodulatory properties is powerful because it does not merely treat the symptoms of vitiligo (depigmented skin) but rather arrest the root cause of vitiligo, which is a far better and more effective way of treatment.
I'm really excited about this interesting and important finding about Black Cumin, and I think you should too.
Here's another interesting
and important finding about Black Cumin ...
and important finding about Black Cumin ...
Phytotherapy ResearchYou know what is immunomodulating properties now.
2004 May;18(5):395-8
Immunosuppressive and cytotoxic properties of Nigella sativa.
Institute of Nutrition and Food Science, University of Dhaka, Dhaka, Bangladesh.
Here's the abstract ...
In this study the volatile oil of Nigella sativa seeds (NSVO) was investigated for its immunomodulating and cytotoxic properties.
A rat model was designed to examine the effect of NSVO on selected immune components.
Long-Evans rats were challenged with a specific antigen (typhoid TH) and treated with NSVO; and the changes produced in their serum antibody titre along with the splenocytes and peripheral immune cells were analysed.
Antibody titre for the experimental animal was found to be 1280 as compared to the 2560 in the control rats. There was a significant (p < style="font-style: italic;">
Results indicate that the NSVO could be considered as a potential immunosuppressive cytotoxic agent.
But ...
What is cytotoxic properties?
Cytotoxic: used to describe a drug that prevents cell division, often used in cancer treatment. Also used to describe a type of cell in the immune system that destroys other cells.
Immunosuppressive cytotoxic agent simply means a substance that can suppress the immune system thus preventing a type of cell in the immune system that destroys other cells.
On the premise that vitiligo is an auto-immune disease, isn't such properties are what we wanted in vitiligo treatment?
I've no problem at all with Black Cumin as an active ingredient in this antivitiligo product.
Do you?
4. Barberry Root
The botanical name of Barberry Root is Berberis vulgaris.
The primary chemical constituents of Barberry include alkaloids (berberine, berbamine, oxyacanthine), chelidonic acid, resin and tannins.
This herb also contains the B-vitamin thiamine, vitamin C, the carotenoids beta-carotene, lutein, and zeaxanthin, chromium, cobalt, and zinc.
Here's an interesting and important finding on the antioxidant and cytoprotective properties of this herb, in relation to another pathogenesis of vitiligo - oxidative stress.
Phytotherapy ResearchCytoprotective means an agent that so protects, protecting cells from noxious chemicals or other stimuli.
2008 Jul;22(7):979-81
Antioxidant and cytoprotective compounds from Berberis vulgaris (barberry).
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University,Columbus, Ohio, USA.
Here's the abstract ...
Activity-guided fractionation of an EtOAc-soluble partition of the MeOH extract from the root bark of Berberis vulgaris L. (barberry), using a hydroxyl radical-scavenging assay, led to the isolation and identification of three phenolic compounds of a previously known structure, N-(p-trans-coumaroyl)tyramine, cannabisin G and (+/-)-lyoniresinol. Of these, cannabisin G and (+/-)-lyoniresinol exhibited antioxidant activity in this bioassay.
Furthermore, it was found that cannabisin G showed cytoprotective activity in cultured MCF-7 cells modulated by hydrogen peroxide.
In order to appreciate the antioxidant and cytoprotective activity in Barberry Root, one has to understand another pathogenesis of vitiligo ... oxidative stress.
What is oxidative stress?
Oxidative stress is an over-accumulation of hydrogen peroxide in the skin. Every person develops hydrogen peroxide in the skin, as a result of natural biological processes. An enzyme called "catalase" normally breaks down the hydrogen peroxide in the skin into water and oxygen.
However, some people with vitiligo may have a problem manufacturing, using or delivering catalase to the skin.
Clinical and experimental dermatologyFrom this scientific study, the antioxidant and cytoprotective properties in Barberry Root may support vitiligo treatment.
2004 Jul;29(4):406-9
Oxidant-antioxidant enzymes and lipid peroxidation in generalized vitiligo.
Department of Dermatology, Zonguldak Karaelmas University, Faculty of Medicine, Zonguldak, Turkey.
Here's the abstract ...
Vitiligo is a common pigmentary disorder of the skin with selective destruction of melanocytes. The pathogenetic mechanisms in vitiligo have not been completely clarified.
The aim of our investigation was to evaluate the oxidative stress in the pathogenesis of generalized vitiligo.
Twenty-seven patients with generalized vitiligo and 24 phototype-, age-, and sex-matched healthy controls were included in this study. We analysed serum levels of malondialdehyde (MDA), nitric oxide (NO), and serum activities of superoxide dismutase (SOD) and xanthine oxidase (XO) in the patients with vitiligo and in the controls.
We found significantly higher levels of MDA and XO activity (P <> 0.05).
These results suggest that lipid peroxidation of cellular membrane of melanocytes by free radicals may have a significant role in the pathogenesis of generalized vitiligo.
Again, I've no problem with Barberry Root as an active ingredient in this antivitiligo product.
Conclusion
From the above scientific studies, it appears this anti-vitiligo product had got the right active ingredients that's scientifically proven to be beneficial for vitiligo treatment.Why?
Let's recap ...
... Because it has photo-sensitizing agent, to cause darkening of your skin especially with the help of natural sunlight, liken to PUVA-SOL.
... Because it has anti-oxidative properties, to guard against oxidative stress, the undesirable accumulation of hydrogen peroxide in your skin.
... Because it has immunomodulatory properties, to modulate your immune system, preventing it from being over-active or under-active.
Conclusion: this anti-vitiligo product may work for you, and it does NOT seems to be a scam.
This is the ONLY anti-vitiligo product
you should bother to try
you should bother to try
I seriously don't think you should take the risk to try any other anti-vitiligo product, simply because the active ingredients used in those anti-vitiligo products are NOT make known to you.
It's just not wise ... for reasons already explained earlier.
Ignore this sincere advice at your own risk.
Does THIS anti-vitiligo really work?
From the above findings, it appears this anti-vitiligo product ... works.
The truth is, if you don't try, you won't know.
The fact that this anti-vitiligo product do have reasonable scientific basis to its claims, is a good and comforting point to start with ... to give it a try.
I've done reviews on many alternative vitiligo treatment products. It's a fact that many alternative treatment products DON'T have any scientific basis to their bodacious claims.
This anti-vitiligo product is one of the rare exceptions.
In addition, this anti-vitiligo product comes with an ...
Exceptionally strong
money-back guarantee
money-back guarantee
QUOTEThat's a pretty credible and generous 2 months free trial.
Minimum two months of regular application is required for the treatment to work. Please make sure that you have used the treatment this long before claiming a refund.
UNQUOTE
Here are money-back guarantee for two other anti-vitiligo product, of which the active ingredients are not revealed.
QUOTEReturn within 15 days ... OR no refund. Pathetic! Toss it! It's unreasonable to expect any results within 15 days.
anti-vitiligo-X
You have right to return unopened/ sealed/empty anti-vitiligo-X within 15 days, and have a refund ...
anti-vitiligo-Y
You have a right to return unopened/sealed anti-vitiligo-Y within 1 month, and have a refund ...
UNQUOTE
Heck, with such a generous 60 day free trial, go ahead and try this anti-vitiligo product for at least 60 days. If you are not happy with the results you get, simply ask for a refund.
Yes, you get your money back
if not your skin color
if not your skin color
So, what have you got to lose?
EXCEPT your vitiligo!
EXCEPT your vitiligo!
CLICK HERE to find out which anti-vitiligo product I'm talking about, if you have NOT done so.
Sorry, I'll NOT reveal here all the other anti-vitiligo products that I strongly suggest that you drop, dump, toss ... and never look at.
Why?
Because that will be seen as bad-mouthing others and it's distasteful. It's my policy to do NO harm to others.
Till next time ...
Here's wishing you speedy repigmentation of your vitiligo lesions with this anti-vitiligo product.
Peace!
Michael DeAngelo
EX-Vitiligo Patient
who is blessed with 100% repigmentation
P.S.: If you have vitiligo at sensitive areas, eg. around the eyes, lips, arm pit, nipple and genital, certain treatments such as steroid and PUVA may not be suitable treatment due to undesirable side-effects - thinning of skin and burns. This anti-vitiligo oil may be a good alternative treatment.
P.P.S.: If you are one of those who refuses to give Elidel pimecrolimus or Protopic tacrolimus a try, due to fear of developing skin cancer from using these drugs, you may want to give this natural product a try then. It's safe.
>>> UPDATE #1 <<<
Money-Back Guarantee
Money-Back Guarantee
After my posting on - "anti-vitiligo - SCAM or Really Work?" few readers had written in and ask a pertinent question ...
QUOTEANSWER:
I want to give this anti-vitiligo a try. But, what if the seller refuses to honour the money-back guarantee, just in case if I do make a refund claim later?
UNQUOTE
If you have a justified refund problem, please write to me giving all the relevant details. I'll post this " unpleasant money-back guarantee experience" of yours in this article to warn other would be users NOT to give this anti-vitiligo a try.
If you google ... "Does Anti-Vitiligo Really Work?" you will see that this article is at #1 google search position. In fact, most anti-vitiligo related search keywords at google will return this blog among the top 10 searches.
Let the product owner know your next course of action, if your justified request for refund is not entertained. I'm very confident this subtle warning would compel him to honor the money-back guarantee, as promised.
Why?
Because this anti-vitiligo product owner will have more to lose, if your unpleasant money-back guarantee story is published in this blog.
Hey, now that you have a powerful bullet to twist the arms of the product owner to honor the refund ... why not use it to the fullest.
Pay ONLY if you see the desired results
in 60 days
in 60 days
Even your dermatologist can't offer such 100% risk-free term.
Try suggesting to your doctor or dermatologist that you'll only pay him IF he has successfully treated you ... no positive results, no pay.
He'll probably ask his nurse to show you the door with an angry face. :-)
You pay your doctor or dermatologist ... irrespective whether you have positive results or not, right?
Try suggesting to your doctor or dermatologist that you'll only pay him IF he has successfully treated you ... no positive results, no pay.
He'll probably ask his nurse to show you the door with an angry face. :-)
You pay your doctor or dermatologist ... irrespective whether you have positive results or not, right?
So much have been said about how we vitiligo victims being scammed left, right and center. It's time, we vitiligo "victims" rise-up and take revenge ... pay only if it works.
Yes, you get your money back
if not your skin color
if not your skin color
Hmm ... that's only fair, huh!
CLICK HERE to give this anti-vitiligo product a try now ... you really have nothing to lose EXCEPT vitiligo ...
>>> UPDATE #2 <<<
Money-Back Guarantee
Unpleasant Experiences
8th October 2008
None at the moment.
Waiting for your feedback ... if any.
Money-Back Guarantee
Unpleasant Experiences
8th October 2008
None at the moment.
Waiting for your feedback ... if any.
y name is Michael DeAngelo, an 
