I've been to the medical library and did some in-depth research on the active ingredients used in
this particular antivitiligo.
SIDE-NOTES
Before the publication of this article, even the producer of this anti-vitiligo product has NO idea of the scientific basis of the active ingredients used in their product, because it was NEVER mentioned in their website earlier. After the publication of this article, they have since taken the main points from my research findings in this article and posted them in their website.
Here are my findings ...1. Coconut OilWhat? Applying coconut oil on my vitiligo lesions?! No way, dude ...
Honestly, that was my initial reaction. However, as I dig deeper and know more of the wonders of coconut oil, I had a paradigm shift.
We all know that oil become rancid pretty fast. This is why leftover foods become stale very fast too.
Do you know that coconut oil is slow to oxidize and thus resistant to rancidity, lasting up to two years due to its high saturated fat content?
This is largely due to
the anti-oxidative effect of coconut oil.
According to a researcher, coconut oil is the only type of oil you should use on your skin because coconut oil will be absorbed easily, keep the skin soft and yet without the greasy feel.
Every 100g of coconut oil contains 0.1mg of Vitamin E Alpha Tocopherol, a well-known potent antioxidant that we all know is beneficial to the skin.
According to an authoritative evidence-based scientific study, coconut oil is proven to be a ...
Safe and effective
moisturizer for your skin
Here's the said scientific study ...
Dermatitis
2004 Sep;15(3):109-16
A randomized double-blind controlled trial comparing extra virgin coconut oil with mineral oil as a moisturizer for mild to moderate xerosis.
Department of Dermatology, Makati Medical Center, Makati City, Philippines.
Here's the abstract ...
BACKGROUND: Xerosis is a common skin condition (1) characterized by dry, rough, scaly, and itchy skin, (2) associated with a defect in skin barrier function, and (3) treated with moisturizers. People in the tropics have effectively used coconut oil as a traditional moisturizer for centuries. Recently, the oil also has been shown to have skin antiseptic effects. A moisturizer with antiseptic effects has value, but there are no clinical studies to document the efficacy and safety of coconut oil as a skin moisturizer.
OBJECTIVE: This study aimed to determine the effectivity and safety of virgin coconut oil compared with mineral oil as a therapeutic moisturizer for mild to moderate xerosis.
METHODS: A randomized double-blind controlled clinical trial was conducted on mild to moderate xerosis in 34 patients with negative patch-test reactions to the test products. These patients were randomized to apply either coconut oil or mineral oil on the legs twice a day for 2 weeks. Quantitative outcome parameters for effectivity were measured at baseline and on each visit with a Corneometer CM825 to measure skin hydration and a Sebumeter SM 810 to measure skin lipids. For safety, transepidermal water loss (TEWL) was measured with a Tewameter TM210, and skin surface hydrogen ion concentration (pH) was measured with a Skin pH Meter PH900. Patients and the investigator separately evaluated, at baseline and at each weekly visit, skin symptoms of dryness, scaling, roughness, and pruritus by using a visual analogue scale and grading of xerosis.
RESULTS: Coconut oil and mineral oil have comparable effects. Both oils showed effectivity through significant improvement in skin hydration and increase in skin surface lipid levels. Safety was demonstrated through no significant difference in TEWL and skin pH. Subjective grading of xerosis by the investigators and visual analogue scales used by the patients showed a general trend toward better (though not statistically evident) improvement with coconut oil than with mineral oil. Safety for both was further demonstrated by negative patch-test results prior to the study and by the absence of adverse reactions during the study.
CONCLUSION: Coconut oil is as effective and safe as mineral oil when used as a moisturizer.
OK, it's proven that coconut oil has anti-oxidative effect and is a safe and effective moisturizer that's good for the skin.
Coconut oil will make your skin softer, smoother and moist.
Hence, I've no problem with coconut oil as an active ingredient in
this antivitiligo product.
Do you?
2. Psoralea Corylifolia (also known as Babachi)
Psoralen occurs naturally in the seeds of Psoralea corylifolia.
Psoralens are
photo-sensitizing agents, meaning they react with ultraviolet (UV) light to cause darkening of the skin.
Psoralen ...
is a time tested treatment for vitiligo
Proof?
PUVA (Psolaren + UVA),
both topical and oral, is the
oldest method of vitiligo treatment.
The name PUVA itself suggests that Psolaren is a
key element in this treatment.
Topica PUVA
In topical PUVA, a thin coat of psoralen is applied to the patient's depigmented patches about 30 minutes before UVA light exposure.
This treatment is often used for people with a small number of depigmented patches (affecting less than 20 percent of the body). It is also used for children 2 years old and older who have localized patches of vitiligo.
Oral PUVA
In oral PUVA therapy, the patient takes a prescribed dose of psoralen by mouth about 2 hours before exposure to artificial UVA light. The doctor adjusts the dose of light until the skin areas being treated become pink.
Oral PUVA therapy is used for people with more extensive vitiligo (affecting greater than 20 percent of the body) or for people who do not respond to topical PUVA therapy.
PUVA-SOL
For both topical and oral PUVA, UVA imust be administered and monitored by a dermatologist.
For patients who cannot go to a PUVA facility, the doctor may prescribe psoralen to be used with
natural sunlight exposure. This is known as PUVA-SOL.
Effectiveness of PUVA
International Journal of Dermatology
1999 Jul;38(7):542-5
PUVA treatment of vitiligo: a retrospective study of Turkish patients.
Department of Dermatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Here's the abstract ...
BACKGROUND:
Psoralen plus ultraviolet A (PUVA) is considered to be the treatment of choice for subtotal vitiligo; however, it is time consuming and carries certain health risks for both patients and physicians. This study attempts to evaluate the efficacy of the treatment in Turkish vitiligo patients.
METHODS:
We have performed a retrospective study of 33 patients with vitiligo who received systemic PUVA therapy during the period 1985 to 1997, and have evaluated their response to treatment.
RESULTS:
Overall, 28 patients (84%) showed some improvement; 12 patients experienced a repigmentation of 51-75% and six patients achieved greater than 75% repigmentation.
The age of the patient, age at onset of the disease, sex, disease duration, and degree of depigmentation prior to initiation of therapy had NO influence on PUVA-induced repigmentation.
From the above findings, the active ingredient Psoralea corylifolia in antivitiligo is expected to have some positive effect on vitiligo treatment, especially when vitiligo lesions are exposed to
natural sunlights, after application of antivitiligo, just like
PUVA-SOL treatment explained above.
Psoralea corylifolia
has oxidative stress properties?
In addition, phenolic compounds in Psoralea corylifolia were shown to be effective in
protecting biological membranes against various oxidative stresses.Here's a scientific study to support this claim.
Phytotherapy Research
2002 Sep;16(6):539-44
Antioxidative components of Psoralea corylifolia (Leguminosae).
Faculty of Engineering, Fukuyama University, Gakuen-cho, Japan.
Here's the abstract ...
A meroterpene and four flavonoids were isolated from the seeds of Psoralea corylifolia as antioxidative components.
Their structures were elucidated by spectral data and identified as bakuchiol (1), bavachinin (2), bavachin (3), isobavachin (4) and isobavachalcone (5).
In particular, meroterpene 1 and flavonoids 4 and 5 showed broad antioxidative activities in rat liver microsomes and mitochondria.
They inhibited NADPH-, ascorbate-, t-BuOOH- and CCl(4)-induced lipid peroxidation in microsomes. They also prevented NADH-dependent and ascorbate-induced mitochondrial lipid peroxidation.
Bakuchiol (1) was the most potent antioxidant in microsomes and the inhibition of oxygen consumption induced by lipid peroxidation was time-dependent.
Furthermore, bakuchiol (1) protected human red blood cells against oxidative haemolysis.
These phenolic compounds in P. corylifolia were shown to be effective in protecting biological membranes against various oxidative stresses.
Oxidative stress is widely accepted as one of the probable cause of vitiligo. Hence, the protective oxidative stress properties in Psoralea corylifolia suggest that it's beneficial for vitiltgo treatment.
Psoralea corylifolia
stimulate the immune system
In another scientific study, Psoralea corylifolia seed extract has been found to
stimulate the immune system in mice.Here's a scientific study to support this claim ...
Fitoterapia
2000 Jun;71(3):223-31
Immunomodulatory and antitumour properties of Psoralea corylifolia seeds.
Ethnomedicine and Ethnopharmacology Division, Tropical Botanic Garden and Research Institute (TBGRI), Palode, Trivandrum, India.
Here's the abstract ...
Psoralea corylifolia seed extract has been found to stimulate the immune system in mice.
Administration of the extract was found to inhibit EAC ascitic tumour growth and stimulate natural killer cell activity, antibody-dependent cellular cytotoxicity, antibody-forming cells and the antibody complement-mediated cytotoxicity during tumour development.
Auto-immunity is another widely accepted probable cause of vitiligo. Hence, the protective oxidative stress properties in Psoralea corylifolia suggest that it's beneficial for vitiltgo treatment.
From all the above positive findings about Psoralea corylifolia on vitiligo, I've no problem with this active ingredient in
this antivitiligo product.
I believe you too.
After all, Psoralen is a time tested treatment for vitiligo, and no one can dispute that simple fact.3. Black CuminBlack cumin refers to seeds derived from a plant with the botanical name Nigella sativa.
Below is a
very important and interesting finding about Nigella sativa.
Read this ...
International Immunopharmacology
2005 Dec;5(13-14):1749-70. Epub 2005 Jul 1
Immunomodulatory and therapeutic properties of the Nigella sativa L. seed
Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, USA.
Here's the abstract ...
A larger number of medicinal plants and their purified constituents have been shown beneficial therapeutic potentials.
Seeds of Nigella sativa, a dicotyledon of the Ranunculaceae family, have been employed for thousands of years as a spice and food preservative.
The oil and seed constituents, in particular thymoquinine (TQ), have shown potential medicinal properties in traditional medicine.
In view of the recent literature, this article lists and discusses different immunomodulatory and immunotherapeutic potentials for the crude oil of N. sativa seeds and its active ingredients.
The published findings provide clear evidence that both the oil and its active ingredients, in particular TQ, possess reproducible anti-oxidant effects through enhancing the oxidant scavenger system, which as a consequence lead to antitoxic effects induced by several insults.
The oil and TQ have shown also potent anti-inflammatory effects on several inflammation-based models including experimental encephalomyelitis, colitis, peritonitis, oedama, and arthritis through suppression of the inflammatory mediators prostaglandins and leukotriens.
The oil and certain active ingredients showed beneficial immunomodulatory properties, augmenting the T cell- and natural killer cell-mediated immune responses.
Most importantly, both the oil and its active ingredients expressed anti-microbial and anti-tumor properties toward different microbes and cancers.
Coupling these beneficial effects with its use in folk medicine, N. sativa seed is a promising source for active ingredients that would be with potential therapeutic modalities in different clinical settings.
The efficacy of the active ingredients, however, should be measured by the nature of the disease.
Given their potent immunomodulatory effects, further studies are urgently required to explore bystander effects of TQ on the professional antigen presenting cells, including macrophages and dendritic cells, as well as its modulatory effects upon Th1- and Th2-mediated inflammatory immune diseases.
Ultimately, results emerging from such studies will substantially improve the immunotherapeutic application of TQ in clinical settings.
Immunomodulatory properties ...
What does that really mean?
Immunomodulatory properties simply means ... having the ability to alter or regulate one or more immune functions.
In other words, it enables immune system modification during treatment: the modification of some aspect of the immune system as part of a treatment, especially the suppression of the immune system in order to encourage the body to accept another part of the same body.
To put it in another way, Black Cumin is an immunosuppressant or an immunostimulator based on its effect on the immune system.
It has the abilities to modulate the immune system, preventing it from being over or under active.
In simple layman's terms, it modulates the immune system accordingly ... not too hot, not too cold ... just right.
On the premise that vitiligo is an
auto-immune disease, meaning skin depigmentation occurs because of an over-active immune system [the immune cells of the body are killing the melanocyte (the cells that produce pigment molecules and give the skin its color)
or the melanocyte are attacking and killing themselves],
the immunomodulatory properties of Black cumin in modulating the immune system, preventing the immune system from being over or under active, is indeed a very powerful property.This immunomodulatory properties is
powerful because it does not merely treat the symptoms of vitiligo (depigmented skin) but rather
arrest the root cause of vitiligo, which is a far better and more effective way of treatment.
I'm
really excited about this interesting and important finding about Black Cumin, and I think you should too.
Here's another interesting
and important finding about Black Cumin ...
Phytotherapy Research
2004 May;18(5):395-8
Immunosuppressive and cytotoxic properties of Nigella sativa.
Institute of Nutrition and Food Science, University of Dhaka, Dhaka, Bangladesh.
Here's the abstract ...
In this study the volatile oil of Nigella sativa seeds (NSVO) was investigated for its immunomodulating and cytotoxic properties.
A rat model was designed to examine the effect of NSVO on selected immune components.
Long-Evans rats were challenged with a specific antigen (typhoid TH) and treated with NSVO; and the changes produced in their serum antibody titre along with the splenocytes and peripheral immune cells were analysed.
Antibody titre for the experimental animal was found to be 1280 as compared to the 2560 in the control rats. There was a significant (p < style="font-style: italic;">
Results indicate that the NSVO could be considered as a potential immunosuppressive cytotoxic agent.
You know what is
immunomodulating properties now.
But ...
What is cytotoxic properties?
Cytotoxic: used to describe a drug that prevents cell division, often used in cancer treatment. Also used to describe a type of cell in the immune system that destroys other cells.
Immunosuppressive cytotoxic agent simply means a substance that can suppress the immune system thus preventing a type of cell in the immune system that destroys other cells.On the premise that vitiligo is an auto-immune disease, isn't such properties are what we wanted in vitiligo treatment?
I've no problem at all with Black Cumin as an active ingredient in this antivitiligo product.
Do you?
4. Barberry RootThe botanical name of Barberry Root is
Berberis vulgaris.
The primary chemical constituents of Barberry include alkaloids (berberine, berbamine, oxyacanthine), chelidonic acid, resin and tannins.
This herb also contains the B-vitamin thiamine, vitamin C, the carotenoids beta-carotene, lutein, and zeaxanthin, chromium, cobalt, and zinc.
Here's an interesting and important finding on the
antioxidant and cytoprotective properties of this herb, in relation to another pathogenesis of vitiligo -
oxidative stress.
Phytotherapy Research
2008 Jul;22(7):979-81
Antioxidant and cytoprotective compounds from Berberis vulgaris (barberry).
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University,Columbus, Ohio, USA.
Here's the abstract ...
Activity-guided fractionation of an EtOAc-soluble partition of the MeOH extract from the root bark of Berberis vulgaris L. (barberry), using a hydroxyl radical-scavenging assay, led to the isolation and identification of three phenolic compounds of a previously known structure, N-(p-trans-coumaroyl)tyramine, cannabisin G and (+/-)-lyoniresinol. Of these, cannabisin G and (+/-)-lyoniresinol exhibited antioxidant activity in this bioassay.
Furthermore, it was found that cannabisin G showed cytoprotective activity in cultured MCF-7 cells modulated by hydrogen peroxide.
Cytoprotective means an agent that so protects, protecting cells from noxious chemicals or other stimuli.
In order to appreciate the antioxidant and
cytoprotective activity in Barberry Root, one has to understand another pathogenesis of vitiligo ...
oxidative stress.What is oxidative stress?
Oxidative stress is an over-accumulation of hydrogen peroxide in the skin. Every person develops hydrogen peroxide in the skin, as a result of natural biological processes. An enzyme called "catalase" normally breaks down the hydrogen peroxide in the skin into water and oxygen.
However, some people with vitiligo may have a problem manufacturing, using or delivering catalase to the skin.
Clinical and experimental dermatology
2004 Jul;29(4):406-9
Oxidant-antioxidant enzymes and lipid peroxidation in generalized vitiligo.
Department of Dermatology, Zonguldak Karaelmas University, Faculty of Medicine, Zonguldak, Turkey.
Here's the abstract ...
Vitiligo is a common pigmentary disorder of the skin with selective destruction of melanocytes. The pathogenetic mechanisms in vitiligo have not been completely clarified.
The aim of our investigation was to evaluate the oxidative stress in the pathogenesis of generalized vitiligo.
Twenty-seven patients with generalized vitiligo and 24 phototype-, age-, and sex-matched healthy controls were included in this study. We analysed serum levels of malondialdehyde (MDA), nitric oxide (NO), and serum activities of superoxide dismutase (SOD) and xanthine oxidase (XO) in the patients with vitiligo and in the controls.
We found significantly higher levels of MDA and XO activity (P <> 0.05).
These results suggest that lipid peroxidation of cellular membrane of melanocytes by free radicals may have a significant role in the pathogenesis of generalized vitiligo.
From this scientific study, the antioxidant and cytoprotective properties in Barberry Root may support vitiligo treatment.
Again, I've no problem with Barberry Root as an active ingredient in this antivitiligo product.
Conclusion
From the above findings, it appears
this antivitiligo product had got the
right active ingredients that's scientifically proven to be beneficial for vitiligo treatment.
Why?
Let's recap ...
... Because it has
photo-sensitizing agent, to cause darkening of your skin especially with the help of natural sunlight, liken to PUVA-SOL.
... Because it has
anti-oxidative properties, to guard against oxidative stress, the undesirable accumulation of hydrogen peroxide in your skin.
... Because it has
immunomodulatory properties, to modulate your immune system, preventing it from being over-active or under-active.
Conclusion: this antivitiligo product may work for you, and it does NOT seems to be a scam.This is the ONLY antivitiligo product
you should bother to try
I seriously don't think you should take the
risk to try any other antivitiligo product, simply because the active ingredients used in those antivitiligo products are NOT make known to you.
It's just
not wise ... for reasons already explained earlier.
Ignore this
sincere advice at your own risk.
Does THIS antivitiligo really work?
From the above findings, it appears
this antivitiligo product ... works.
The truth is,
if you don't try, you won't know.The fact that
this antivitiligo product do have
reasonable scientific basis to its claims, is a good and comforting point to start with ... to give it a try.
I've done reviews on many alternative vitiligo treatment products. It's a fact that many alternative treatment products DON'T have any scientific basis to their bodacious claims.
This antivitiligo product is one of the
rare exceptions.
In addition,
this antivitiligo product comes with an ...
Exceptionally strong
money-back guarantee
QUOTE
Minimum two months of regular application is required for the treatment to work. Please make sure that you have used the treatment this long before claiming a refund.
UNQUOTE
That's a pretty credible and generous 2 months
free trial.
Here are money-back guarantee for two
other antivitiligo product, of which the active ingredients are not revealed.
QUOTE
antivitiligo-X
You have right to return unopened/ sealed/empty antivitiligo-X within 15 days, and have a refund ...
antivitiligo-Y
You have a right to return unopened/sealed antivitiligo-Y within 1 month, and have a refund ...
UNQUOTE
Return within 15 days ... OR no refund. Pathetic! Toss it! It's unreasonable to expect any results within 15 days.
Heck, with a generous 60 day
free trial, go ahead and try
this antivitiligo product for
at least 60 days. If you are
not happy with the results you get, simply ask for a refund.
Yes, you get your money back
if not your skin color
So, what have you got to lose?
EXCEPT your vitiligo!
CLICK HERE to find out
which antivitiligo product I'm talking about, if you have NOT done so.
Sorry, I'll NOT reveal here all the
other antivitiligo products that I
strongly suggest that you drop, dump, toss ... and never look at.
Why?
Because that will be seen as bad-mouthing others and it's
distasteful. It's my policy to do NO harm to others.
Till next time ...
Here's wishing you speedy repigmentation of your vitiligo lesions with
this antivitiligo product.
Peace!
Michael DeAngeloEX-Vitiligo Patientwho is blessed with 100% repigmentationP.S.: If you have vitiligo at
sensitive areas, eg. around the eyes, lips, arm pit, nipple and genital, certain treatments such as steroid and PUVA may not be suitable treatment due to undesirable side-effects - thinning of skin and burns.
This antivitiligo oil may be a good alternative treatment.
P.P.S.: If you are one of those who refuses to give Elidel pimecrolimus or Protopic tacrolimus a try, due to fear of developing skin cancer from using these drugs, you may want to give this natural product a try then. It's safe.
y name is Michael DeAngelo, an 
